Publications

Publications

1. Cowin A.J, Adams DH, Strudwick XL, Chan H,  Hooper JA, Sander GR, Rayner TE, Matthaei KI, Powell BC, Campbell HD (2007) Flightless I deficiency enhances wound repair by increasing cell migration and proliferation. Journal of Pathology 211(5):572-581.
2. Kopecki Z, and Cowin AJ (2007). Flightless I: An actin-remodelling protein and an important negative regulator of wound repair. International Journal of Biochemistry and Cell Biology, 40(8):1415-9.
3. Adams DH, Strudwick XL, Hooper JA, Matthaei KI, Powell BC, Campbell HD Cowin A.J, (2008). Gender specific effects on the actin-remodelling protein Flightless I and TGF-beta1 contribute to impaired wound healing in aged skin. International Journal of Biochemistry and Cell Biology. 40(8):1555-69.
4. Kopecki Z, Arkell RM, Powell BP Cowin AJ (2009). Flightless I regulates hemidesmosome formation and integrin mediated cellular adhesion and migration during wound repair. Journal Investigative Dermatology, 129, 2031-2045
5. Adams DH, Ruzehaji N, Strudwick XL, Greenwood JE, Campbell HD, Arkell RM, Cowin AJ (2009). Attenuation of actin-remodelling protein, Flightless I, in partial-thickness burn injuries improves wound healing via modulation of TGF-β1 and TGF-β3. British Journal Dermatology, Aug;161(2):326-36.
6. Waters JM, Lindo J, Arkell RM, Cowin AJ. (2011). Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibri19ssa Model Accepted Nov 2010 Journal Investigative Dermatology, 131, 838-47
7. Kopecki Z, O’Neil G, Arkell RM, Cowin AJ. (2011). Flightless I regulates focal adhesion by inhibiting paxillin phosphorylation and suppressing adhesion signaling proteins Src and p130Cas. Journal Investigative Dermatology, Jul;131(7):1450-9.
8. Thomsen N, Chappell A, Adams DA, Ali RG, Jones T, Matthaei KL, Campbell HD, Cowin AJ and Arkell RM (2011) Mouse strains for the ubiquitous or conditional overexpression of the Flii gene Genesis Aug;49(8):681-8
9. Lin CH, Waters JM, Powell BC, Arkell RM, Cowin AJ. (2011) Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early gestation fetal wounds improves healing. Mammalian Genome Jun;22(5-6):341-52.
10. Kopecki Z, Arkell RM, Strudwick XL, Hirose M, Ludwig RJ, Kern JS, Bruckner-Tuderman L, Zillikens D, Murrell DF and Cowin AJ (2011) Overexpression of the Flii gene increases dermal-401-13. epidermal blistering in an autoimmune ColVII mouse model of Epidermolysis Bullosa Acquisita J Pathology Nov;225(3) 401-13
11. Jackson JE, Kopecki Z, Adams DH, Cowin AJ. (2012) Flii neutralising antibodies improve wound healing in porcine pre-clinical studies. Wound Repair and Regeneration Jul-Aug;20(4):523-36.
12. Lei N, Franken L, Ruzehaji N, Offenhäuser C, Cowin AJ and Murray RZ. (2012) Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion Journal Cell Science Sep 15;125(Pt 18):4288-96.
13. Ruzehaji N, Grose R, Krumbiegel D, Wallace H, Stacey M, Fitridge R, Cowin AJ (2012) Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: neutralizing its activity in chronic but not acute wound fluid improves cellular proliferation European Journal Dermatology 22(6):740-50.
14. Cowin AJ, Lei N, Franken L, Ruzehaji N, Offenhäuser C, Kopecki Z, Murray RZ. (2012) Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation. Communicative & Integrative Biology 5 (6), 0—1
15. Kopecki Z, Ruzehaji N, Turner C, Iwata H, Ludwig RJ, Zillikens D, Murrell DF Cowin AJ (2013) Topically applied Flightless I neutralising antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisita Journal Investigative Dermatology 2013 Apr;133(4):1008-16. doi: 10.1038/jid.2012.457. Epub 2012 Dec 6.
16. Ruzehaji N, Mills SJ, Melville E, Arkell RM, Fitridge RA, Cowin AJ (2013) Influence of Flightless I on Toll-Like Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing. BioMed Research International 2013:389792. doi: 10.1155/2013/389792. Epub 2013 Feb 18.
17. Kopecki Z. Yang G.N. Arkell, R.M. Jackson, J.E., Melville, E. Iwata H. Ludwig, R.J. Zilikens D. Cowin A.J. (2014) Flightless I overexpression impairs skin barrier development, function and recovery post skin blistering Journal of Pathology Apr;232(5):541-52.
18. Ruzehaji N, Kopecki Z, Melville E, Appleby SL,. Bonder CS, Arkell RM , Fitridge R, Cowin AJ (2014) Attenuation of Flightless I improves healing in a murine model of type 1 diabetes through increased angiogenesis in the wounds. Diabetologia Feb;57(2):402-12
19. Chan H, Kopecki Z, Waters JM, Powell BC, Arkell RM, Cowin AJ (2014) Cytoskeletal protein Flightless I differentially affects TGF-β isoform expression in both in vitro and in vivo wound models. Wound Practice and Research 22 (3) 169-181
20. Martens P, Ly M, Adams DH, Riddle K, Strudwick X, Cowin AJ, Poole-Warren LA. (2015) In vivo delivery of functional Flightless I siRNA using layer-by-layer polymer surface modification Journal of Biomaterials Applications Apr 2. pii: 0885328215579422
21. Turner CT, Waters J, Jackson J, Arkell RM Cowin AJ (2015). Fibroblast specific up-regulation of Flightless I impairs wound healing. Experimental Dermatology. 24(9):692-7. doi: 10.1111/exd.12751.
22. Kopecki Z, Yang GN, Jackson, JE, Melville E, Caley MP, Murrell DF, Darby I, O’Toole EA, Samuel MS Cowin AJ. (2015) Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression Oncotarget Nov 3;6(34):36426-40. doi: 10.18632/oncotarget.5536
23. Cameron AM, Turner CT, Adams DH, Jackson JE, Melville E, Arkell RM, Anderson PJ, Cowin AJ (2016) Flightless I is a Key Regulator of the Fibroproliferative Process in Hypertrophic Scarring and a Target For a Novel Anti-Scarring Therapy. British Journal of Dermatology 174(4):786-94. Nov 1. doi: 10.1111/bjd.14263
24. Chong HT, Yang GN, Ibbetson, SSJ, Kopecki Z, Cowin AJ. (2016). Reducing Flightless I expression decreases severity of psoriasis in an imiquimod-induced murine model of psoriasiform dermatitis British Journal of Dermatology. Accepted June 2016
25. Turner CT, McInnes SJP, Melville E, Cowin AJ*, Voelcker NH* (2016) Delivery of Flightless I neutralizing antibody from porous silicon nanoparticles improves wound healing in diabetic mice. Advanced Healthcare Materials Jan;6(2). doi: 10.1002/adhm.201600707.
26. Turner CT, Hasanzadeh MK, Melville E, Delalat B, Harding F, Mäkilä E, Salonen J, Cowin AJ, Voelcker NH. (2017) Delivery of Flightless I siRNA from porous silicon nanoparticles improves wound healing in mice. ACS Biomater. Sci. Eng., 2017, 2 (12), pp 2339–2346
27. Strudwick XL, Waters JM, Cowin AJ (2017) Flightless I expression enhances murine claw regeneration following digit amputation. Accepted July Journal of Investigative Dermatology Jan;137(1):228-236 doi: 10.1016/j.jid.2016.08.019.
28. Haidari H, Zhang Q, Melville E, Kopecki Z, Song M, Cowin AJ, Garg S (2017). Development of Topical Delivery Systems for Flightless Neutralizing Antibody. Journal of Pharmaceutical Sciences Mar 20. pii: S0022-3549(17)30169-7.
29. Kopecki Z, Stevens N, Yang G, Melville E, Cowin AJ (2018) Recombinant Leucine Rich Repeat Flightless Interacting Protein-1 improves healing of acute wounds through its effects on proliferation, inflammation and collagen deposition International Journal of Molecular Sciences. Jul 10;19(7). pii: E2014. doi: 10.3390/ijms19072014.
30. He J, Hou P, Chen Q, Wang W, Sun X, Yang P, Li Y, Yao L, Li X, Jiang X, Chien K, Zhang Z, Wu Q, Cowin AJ, Wu Q, Chen H (2018) Blocking p62 recognition of LC3 by Flightless-I impedes selective autophagy and promotes breast cancer progression. Cancer Research Sep 1;78(17):4853-4864. doi: 10.1158/0008-5472.CAN-17-3835. Epub 2018 Jun 13.
31. Kopecki Z., Stevens N.E, Chong H.T., Yang G.N.and Cowin A.J. 2018 Flightless I alters the inflammatory response and autoantibody profile in an OVA-induced atopic dermatitis skin-like disease. Frontiers in Immunology Aug 10;9:1833. doi: 10.3389/fimmu.2018.01833. eCollection 2018511